Dose Proportionality Study (Ascending Dose)

In the analysis of dose proportionality, by administering different doses of drugs, testing the plasma drug concentration of the compound in the animal body, and calculating the drug exposure, the relationship between the administered dose of the small molecule drug and the body exposure can be calculated.

Dose Proportionality Study Protocol

Species Mouse, rat, dog, monkey, cat, rabbit, guinea pig
Dosing route P.O., I.V., I.M.; I. P. etc
Groups Multiple groups with different dosages
Dosing frequency Single dose
Number of animals 3 per group
Time points 5min, 15 min,30 min, 1 hr, 2 hr, 4 hr, 8 hr, 24 hr (other time points can be chosen)
Analysis method LC-MS/MS,standard curve,
Data analysis WinNonlin
Turn Around Time 5 working days
Integrate Drug Discovery Service
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