Cassette PK (I.V.)

In the process of compound PK screening, in order to save costs, molecules with similar physical and chemical properties can be combined to perform a Cassette PK experiment, usually 3-5 molecules can be tested in one experiment. The reference protocol of the combined PK experiment is as follows.

Cassette PK Protocol

Species Mouse, rat, dog, monkey, cat, rabbit, guinea pig
Dosing route P.O., I.V., I.M.; I. P. etc
Groups One group,P.O.or I.V.;
Dosage P.O.: 5-10 mpk,I.V.:1-2 mpk for each compound
Dosing frequency Single dose
Number of animals 3 per group
Time points 5min, 15 min,30 min, 1 hr, 2 hr, 4 hr, 8 hr, 24 hr
Analysis method LC-MS/MS
Data analysis Winnonlin
Turn Around Time 5 days
Integrate Drug Discovery Service
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