Tissue Distribution Analysis

When the compound enters the body, it will be distributed in various organs along with the blood circulation. Since different organs have different physiological structures and internal physical and chemical properties (such as pH, etc.), the compounds are unevenly distributed in various organs. By measuring the drug concentration of the compound in various organs in the body and studying the tissue distribution of the compound in the animal body, it is helpful to choose the indication of the compound, and it can also help to understand the toxicological problems that may occur in the later period of the compound development.
At TruwayBio, we use non-radioactive methods to study the distribution of compounds in rats and mice.

Tissue Distribution Analysis

Species Mouse, rat,
Dosing route P.O., I.V., I.M.; I. P. etc
Groups multiple groups, one group per time point
Dosage TBD
Dosing frequency Single dose or repeat dose
Number of animals 3 per group
Time points TBD
Tissue Analyzed Heart, liver, spleen, lung, kidney, gallbladder, small intestine, large intestine, brain, reproductive system, bone marrow, pancreas, muscle, fat, etc.
Analysis method LC-MS/MS
Integrate Drug Discovery Service
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