Service Flowchart

Service Coverage

Enzymatic Assay

Cell Based Assay

1. Cell Proliferation Assay
2. PK-guided Cell Proliferation Assay (PCPA）
3. Screening with iPSC-derived tumor cells
4. CRISPR-Cas9 genome editing
5. Barcoded Ba/F3 cells stably expressing onco-kinase
6. In vitro Combination Study
7. wash-out experiment

In Vitro ADME

1. Solubility Test
2. Microsome Stability Tests
3. Hepatocytes Stability Tests
4. CYP450 Inhibition
5. CaCO2 Permeability Test
6. MDCK-MDR Permeability Test
7. Plasma Protein Binding
8. Red Blood Cell Partitioning
9. Solubility Test
10. LogD
11. Microsome Stability Tests (Mouse, Rat, Dog, Monkey
12. Hepatocytes Stability Tests
13. CYP450 Inhibition (1A2,2C9,2C19,2D6,3A4)
14. CaCO2 Permeability Test
15. MDCK-MDR Permeability Test
16. Plasma Protein Binding
17. Red Blood Cell Partitioning (Blood/Plasma Ratio)

In Vivo DMPK

1. Single Dose PK
2. Dose Proportionality (Ascending Dose)
3. Dose Linearity (Multiple Dose)
4. Cassette PK (I.V.)
5. Blood-brain Barrier
6. Tissue Distribution
7. Mass Balance
8. Toxicokinectics
9. PK Formulation Screening And Optimization
10. Single Dose PK
11. Dose Proportionality (Ascending Dose)
12. Dose Linearity (Multiple Dose)
13. Cassette PK (I.V.)
14. Blood-brain Barrier
15. Tissue Distribution
16. Mass Balance
17. PK Formulation Screening And Optimization

PharmacoDynamics（PD）

1. PK-PD Relationship

Syngeneic tumor models

1. Breast cancer models
2. Colorectal cancer models
3. Renal cancer models
4. Liver cancer models
5. Melanoma models
6. Pancreatic cancer models

Xenograft tumor Models

1. Breast cancer models
2. Colorectal cancer models
3. Epidermal cancer models
4. Gastric cancer models
5. Glioblastoma models
6. Leukemia models
7. Liver cancer models
8. Lung cancer models
9. Lymphoma models
10. Melanoma models
11. Ba/F3-derived cell models
12. Pancreatic cancer models
13. Ovarian cancer models
14. Prostate cancer models

PBMC-humanized Xenograft tumor Models

1. JeKo-1
2. A375
3. HCT116

Technology

1. Cell line establishment
2. Stem Cell Related
3. Enzymatic Assay Development and Validation
4. Animal Operation

Resources

1. Research Updates
2. Pipeline Analysis

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